More potent than fentanyl? 5 things to know about the illicit drug cychlorphine

Read the original article on the Ploitifact website.

IF YOUR TIME IS SHORT
  • Cychlorphine is a lab-made opioid that laboratory tests found to be more potent than fentanyl.
  • Health officials warn that the drug has been found in illicit drugs, including powders and counterfeit pills made to look like prescription medications.
  • Cychlorphine’s strength can increase the risks of overdosing.

After years of fentanyl causing fatal overdoses, public officials are now warning of an even more powerful opioid.

After years of fentanyl causing fatal overdoses, public officials are now warning of an even more powerful opioid.

Cychlorphine (sy-KLOR-feen) is a synthetic, or lab-made, opioid — specifically, a class of drugs known as orphines. Created by researchers who were trying to find powerful painkillers in the 1960s, orphines were ultimately considered too strong and dangerous, and the U.S. Food and Drug Administration never approved cychlorphine for medical use.

Cychlorphine is a Schedule I drug that cannot be possessed or sold under federal law, but it has been increasingly linked to overdoses after China banned synthetic opioids called nitazenes.

People who track illicit drugs in the United States first identified cychlorphine in the drug supply in 2024, and Reddit users were talking about it online that same year. The drug is now making headlines in connection with U.S. overdose deaths.

It was linked to a 16-year-old’s death in San Francisco in April. And in Knoxville, Tennessee, officials said cychlorphine had been detected in about 50 suspected overdose deaths from July 2025 to early June.

Officials in Louisiana and Los Angeles County have issued public alerts warning residents of its risks as well.

How prevalent is cychlorphine in the U.S.? 

In 2024, there was one report of cychlorphine in the U.S. drug supply, according to the White House Office of National Drug Control Policy. In 2025, there were 16 reports of it in 10 states.

Nationally, orphines don’t currently appear to be widespread, but “prevalence and trends are hard to discern,” said Jason R. Williams, a research scientist at the University of Washington’s Addictions, Drug & Alcohol Institute.

Hospitals and medical examiners’ toxicology tests and even crime labs sometimes fail to detect any given drug until it becomes a substance that officials are interested in tracking or collecting data on, he said.

The National Drug Control Policy office said it is currently most prevalent in Ohio, Texas and Tennessee.

Following a fatal overdose in Los Angeles County, public health officials there warnedthat cychlorphine is being mixed into the illicit drug supply without people’s knowledge. It has been found in powders, rocks or crystals, liquids and counterfeit pills made to look like prescription medications, they said.

How strong is cychlorphine? 

The Drug Enforcement Administration describes fentanyl — a synthetic opioid that is approved for medical use — as about 100 times more potent than morphine.

Laboratory tests show cychlorphine is about 10 times more potent than fentanyl, said Alex Krotulski, director of toxicology and chemistry at the Center for Forensic Science Research and Education.

“That’s the only data that we have right now,” Krotulski said in July. Fentanyl has been studied in humans, but cychlorphine has not been studied in humans or animals, he said. “So we’re really finding out in real time what its effects on humans are.”

The drug’s potential effect on a person, however, depends on the dose, not just the cychlorphine’s potency.

Read the rest of the article on the Politifact website.

September 21, 2026: Pill press bill passes House as owners of LFA Machines arrested

Read the original article on the Partnership for Safe Medicines website.

Three senior employees of a pill press company have been arrested as the U.S. House unanimously passes the Stop Pills That Kill Act. 

Two principal managers and one former long-time employee at LFA Machines, a company selling pill presses and tableting machines, have been arrested. Federal investigators say years-long investigations have not only led to the seizure of the company’s machines at clandestine labs nationwide, but also allege the men sold products to consumers knowing, intending, or having reasonable cause to believe they would be used to manufacture counterfeit pills. In August, an Arizona grand jury indicted LFA Machines and the three men on six counts that each carry a maximum penalty of four years in prison and fines. 

This comes as the U.S. House unanimously passed the Stop Pills That Kill Act (H.R. 8005), legislation that is aimed at disrupting the use of these illicit pill presses to manufacture counterfeit pills. The bill would require pill presses and key components to be serialized, strengthen penalties for removing identifiers or knowingly supplying equipment for illegal drug production, and direct the DEA to develop a strategy addressing counterfeit pills containing fentanyl and other dangerous substances. The legislation comes amid continued pill press seizures nationwide, including 13 states identified in PSM’s latest report and 29 machines seized by the DEA during a recent enforcement initiative.

Continue reading the article on the Partnership for Safe Medinces website.

PSM pill press update, February – July 2026

Illicit pill presses are an engine for counterfeit medicine production, creating fake prescription pills with fentanyl or methamphetamine, which have harmed Americans for over a decade, but also fake blood thinners, substandard Viagra, and bootlegged anxiety medicine.

Fayetteville police urge community members to carry Narcan due to extreme opioid overdoses

The Fayetteville Police Department said they have seen an increase in drug overdoses from synthetic opioids in the past several months. Police are encouraging community members to carry Naloxone (Narcan). It is a nasal spray that will rapidly reverse an opioid overdose and restore breathing.

Fayetteville police are urging community members to carry Narcan due to a large number of opioid overdoses in the area. 

The Fayetteville Police Department said they have seen an increase in drug overdoses from synthetic opioids in the past several months. Police are encouraging community members to carry Naloxone (Narcan). It is a nasal spray that will rapidly reverse an opioid overdose and restore breathing. 

“Our immediate priority is preventing the additional loss of life. Synthetic opioids do not discriminate, and one exposure can be fatal,” said Fayetteville Police Department Major Shawn Strepay. “We ask everyone in our community to take this warning seriously and to call 911 immediately if an overdose is suspected.”

Police were called to a location on Saturday where three people were experiencing overdoses. Upon arrival, officers began lifesaving measures and called EMS. Two people died, and one person was taken to the hospital in serious condition. 

People around Fayetteville agreed that carrying Narcan is a smart preventative measure while acknowledging the need for addiction resources.

“Even though Narcan is a very important preventative measure, I think there’s more things that could get to the root of the issue before that,” said Indie Luther, a Fayetteville resident.

“We urge friends and family members to have those difficult, but necessary, conversations with loved ones struggling with substance abuse. Warn them about this circulating danger and encourage them to seek help before it is too late,” Strepay said.

That message was echoed by another resident who works with Fayetteville Pride, which an organization supporting the city’s LGBTQ+ community and allies.

“Down here especially we have a lot of unhoused people,” said Krystal Maddox. “We do a lot of community activities and a lot of work in the community, so I know a lot of our members carry it.”

Where to find Naloxone (Narcan):
  • Naloxone is available for free from the Cumberland County Department of Public Health, located at 1235 Ramsey St.
  • Local pharmacies will offer Nalaxone without a prescription.
  • For more information on distribution, visit naloxonesave-nc.org

PUBLIC SERVICE ANNOUNCEMENT: Fentanyl Awareness & Safety

The Fayetteville Police Department is urging our community to stay informed about the dangers of fentanyl a synthetic opioid that is up to 50 times stronger than heroin and 100 times stronger than morphine.

A lethal dose of fentanyl can be as small as 2 milligrams—roughly the size of a few grains of salt.

Recorded overdoses in NC down 27% midway through 2026. Local departments warn of fentanyl spike

Read the original article and watch the video on the WRAL News website.

Data from the Department of Health and Human Services shows midway through 2026, North Carolina is seeing a 27% reduction of reported opioid overdoses across state emergency departments. 

Between January and June, to include six months of DHHS data, there are 2,031 reported opioid overdoses in the state. That’s down by more than 700 overdoses compared to the same period of time last year. 

Illicit opioids, which includes fentanyl, make up more than half of the emergency department visits in the state.  

This comes six months after WRAL reported that North Carolina, as a state, saw another consecutive year of declining opioid and fentanyl overdose numbers. An analysis of state health data showed that opioid overdose hospitalizations had decreased by more than 20% in the last year, marking two consecutive years of declining emergency department visits in North Carolina. The same data source shows similar trends for fentanyl positive deaths, which decreased by 24% in the last year. 

Even still, local police departments are issuing public safety notices about localized spikes in suspected fentanyl.

In Fayetteville, policer offers report an increase of overdoses believed to be caused by fentanyl in the local community. 

“The increase has prompted concern that particularly potent or contaminated illegal drugs may currently be circulating in the Fayetteville area,” a spokesperson for the department said. 

This rare spike comes as Cumberland County is experiencing a drastic reduction in overdoses reported to hospitals. Monthly DHHS data shows there are 33 reported cases so far this year, down from 95 over the same window of time last year. 

Illicit opioids, which includes fentanyl, make up more than half of the emergency department visits in the state.  

This comes six months after WRAL reported that North Carolina, as a state, saw another consecutive year of declining opioid and fentanyl overdose numbers. An analysis of state health data showed that opioid overdose hospitalizations had decreased by more than 20% in the last year, marking two consecutive years of declining emergency department visits in North Carolina. The same data source shows similar trends for fentanyl positive deaths, which decreased by 24% in the last year. 

Even still, local police departments are issuing public safety notices about localized spikes in suspected fentanyl.

In Fayetteville, policer offers report an increase of overdoses believed to be caused by fentanyl in the local community. 

“The increase has prompted concern that particularly potent or contaminated illegal drugs may currently be circulating in the Fayetteville area,” a spokesperson for the department said. 

This rare spike comes as Cumberland County is experiencing a drastic reduction in overdoses reported to hospitals. Monthly DHHS data shows there are 33 reported cases so far this year, down from 95 over the same window of time last year. 

By the numbers: Hospitalizations, deaths track down

Statewide, North Carolina recorded 4,960 emergency department visits related to opioid overdoses in 2025. That marks a 21% decrease in the last year, and a 48% decrease since 2023 when the state recorded a record number of 9,624.

In total, overdose emergency department visits decreased by 14% between 2024 and 2025. Last year’s 10,627 cases still mark a 43% reduction since 2023. 

Total Overdose Emergency Department visits

WRAL analyzed data across the Raleigh area, including the North Carolina counties that surround the capital city. Eight counties did not offer county-level reporting. The year-over-year data revealed that rural counties are among those that have seen the largest gains in opioid hospitalization reduction from a per capita standpoint.

“Since the spike stream of the pandemic, we’re following national trends and exceeding national trends. Not only state but county-level data,” Dr. Kelly Crosbie says, Director of DHHS’ Division of Mental Health, Developmental Disabilities, and Substance Use Services

Percent change between 2024 and 2025
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